reimagining
science of
containment
quality

A commitment to advancing sensory research and development beyond physics to accelerate technological breakthroughs in package integrity testing.

Reimagining
science of
containment
quality

A commitment to advancing sensory research and development beyond physics to accelerate technological breakthroughs in package integrity testing.

Life Sciences

Container Closure Integrity

Food & Nutrition

Package & Seal Quality

Plastics

Leak Detection

Technologies

vacuum decay leak testing

Vacuum Decay

Vacuum decay has been substantiated as one of the most practical and sensitive vacuum-based leak detection methods. This test gives a reliable, reproducible and accurate quantitative result and a pass or fail determination. The ASTM F2338 standard vacuum decay test method was developed using PTI’s VeriPac instruments. It is also listed in ISO 11607 and referenced in United States Pharmacopeia Chapter on CCI. VeriPac's non-destructive technology is capable of detecting package leaks and invisible defects using absolute pressure or differential pressure transducer leak test system.

microcurrent hvld technology

Microcurrent HVLD

PTI packaging and inspection systems revolutionized the conventional HVLD method and introduced a groundbreaking new technology for the integrity testing for all parenteral and biological products including low conductivity liquids such as sterile water for injection (WFI). This unique method known as the Microcurrent HVLD utilizes about 50% less voltage and exposes the product and environment to less than 5% of the voltage when compared to conventional HVLD solutions. The Microcurrent HVLD test method is capable of detecting the presence and location of pinholes, micro-cracks, stopper/plunger leaks, non- visible leaks under crimping and many other defects.

helium leak detection

Helium Leak Detection

Helium leak testing is defined as the act of finding leaks in different types of enclosed or sealed systems using helium as a “tracer” gas and its concentration is measured as it escapes due to leakage. A vial, consisting of a container and elastomeric closure, is a good example of a package system. A vial is helium-filled & is subjected to vacuum. The amount of helium escaping that package is quantitatively measured and stated as a leak rate. Other examples include a prefilled syringe, a foil pouch or a cold form blister card.

Pressure Decay leak detection

Pressure Decay

Various applications like plastic bottles and containers, food, beverage and pharmaceutical industries require online leak detection of empty containers before filling and sealing process. Leak testing is also an essential step to assure complete container integrity. PTI’s VeriCon Series offers a complete line of leak tester configurations to accommodate various container specifications and application specific test performance using the pressure decay leak testing method. All VeriCon systems utilize high resolution non-drifting transducers (either pressure transducers or vacuum transducers) for consistent leak detection.

Pressure Decay leak detection

Pressure Decay

Various applications like plastic bottles and containers, food, beverage and pharmaceutical industries require online leak detection of empty containers before filling and sealing process. Leak testing is also an essential step to assure complete container integrity. PTI’s VeriCon Series offers a complete line of leak tester configurations to accommodate various container specifications and application specific test performance using the pressure decay leak testing method. All VeriCon systems utilize high resolution non-drifting transducers (either pressure transducers or vacuum transducers) for consistent leak detection.

Airborne Ultrasound for seal quality inspection

Airborne Ultrasound

A strong seal is not necessarily an airtight one, and the flow of gas or liquid through the seal (leak) is just one type of seal defect. As such, there is a fundamental challenge to any leak testing method, whether it is a fish tank-bubble, vacuum deferential, or helium test: none of these methods detect non-leaking seal defects. PTI’s proprietary Airborne Ultrasound technology is a non-destructive and non-invasive seal quality inspection method that can be used for many material types such as Tyvek, paper, foil, film, aluminum, plastic & poly. Various types of defects, visible and invisible, leaking and non-leaking, process-related and random, are detectable.

force decay leak test

Force Decay

The VeriPac 410 inspection technology platform combines the sensitivity and reliability of PTI’s vacuum decay technology while introducing a force-based measurement to enhance results. The 410’s force decay technology is capable of measuring force from the surface deflection of a package during a normal vacuum based test cycle. This force measurement of the package surface allows the VeriPac 410 to identify which package is defective while also being able to leak test packages with minimal headspace. The VeriPac 410 force decay technology has been successfully validated on multiple package categories including blister packages, transdermal patch sachets, and low headspace suture packs.

optipac leak test

Volumetric Imaging

The OptiPac One-Touch Tool-less system is designed for non-destructive blister package leak detection. The OptiPac uses a volumetric imaging technology to measure the motion of a blister package under vacuum to detect leaks. The interface is practical and simple to setup with new blister package formats, requiring no tooling changeover or complex parameter adjustments experienced with other non-destructive blister package inspection systems. The system captures the volumetric data from each cavity, adapting to different cavity shapes, sizes and arrangements of different blister pack formats.

Technologies

Applications

Leaders in container closure integrity

PTI understands that container closure integrity testing (CCIT) of parenteral products is essential during the entire product lifecycle until it reaches the patient. Any breach in the package can cause product deterioration from microbial contamination, exposure to gases, water vapor and loss of solvent. PTI’s non-destructive inspection technologies verify container closure system integrity with deterministic quantitative test methods for vials, ampoules, syringes, cartridges and auto-injectors.

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vial integrity testing

The OptiPac One-Touch Tool-less Leak Detection System is a deterministic non-destructive technology designed specifically for multi-cavity blister packs. OptiPac utilizes volumetric imaging under vacuum with topographic imaging to detect the presence and location of leaks. The OptiPac is engineered and designed with One-Touch Technology to achieve a rapid test cycle requiring no changeover or sample preparation.


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optipac leak testing

The VeriPac 410 inspection system offers non-destructive seal and leak detection for blister packs, sachets, and pouches with low headspace (suture packs, transdermal product packaging).


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veripac 410 leak test

VeriPac 400 series utilize an ASTM approved vacuum decay leak test method F2338, to evaluate and analyze package integrity with precision and repeatability. The test system uses cutting edge innovation to provide sensitive and robust detection of defects and is designed to inspect flexible, rigid and semi-rigid packaging


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veripac leak

Helium leak testing refers to the act of finding leaks in different types of sealed systems using helium as a “tracer” gas. Due to its extreme sensitivity, a helium-based test method has been proven to be the most effective method for determining the integrity of a blister pack. The helium that has been sealed inside the packaging system escapes through tiny channels in the package, and this is how the test procedure detects it.


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helium leak testing

VeriPac inspection systems utilize an ASTM approved vacuum decay leak test method (F2338) recognized by the FDA as a consensus standard for package integrity testing. This test method was developed using VeriPac leak test instruments. This vacuum decay method developed by PTI’s VeriPac instruments are capable of detecting leaks in the single digit micron range.


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seal quality testing

PTI’s proprietary Airborne Ultrasound technology is a non-destructive and non-invasive seal quality inspection method. This is a referenced technology in the new USP <1207> Chapter Guidance as a deterministic test method for seal quality testing, an ASTM Test Method F3004 and FDA Recognized Standard for seal quality integrity testing.


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veripac flex systems

Seal-Scan® and Seal-Sensor systems utilize non-contact airborne ultrasonic technology for seal analysis of pouches and flexible packaging. This technology is a deterministic, quantitative test method and also an ASTM Test Method F3004-13. Seal-Scan is a high resolution method that inspects and analyzes pouch seals non-destructively offline. Seal-Sensor is designed for 100% online pouch seal inspection.


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Seal Quality Testing and analysis

VeriPac FLEX Systems are versatile non-destructive package inspection systems designed for pouches and other flexible packaging. VeriPac inspection systems provide a definitive PASS or FAIL as well as quantitative data that correlates to a leak rate. The VeriPac FLEX Systems provide unparalleled sensitivity, reliability and practicality in testing a wide range of flexible package formats and sizes with no change-over of settings or tooling.


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veripac flex systems

CCI testing of Intravenous Bags

Intravenous (IV) bags are crucial in delivering fluids or medication quickly. Leaking parenteral packages are considered an extremely high risk as they deliver fluid directly into the bloodstream and have a high potential for microbial growth, requiring the need for sensitive and reliable CCI testing. IV bags can be effectively tested using VeriPac Vacuum Decay technology. PTI’s VeriPac Vacuum Decay technology is capable of detecting package leaks and invisible defects using a differential pressure transducer leak test system.

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iv bags

The VeriCon 126+ is a robust leak test system that operates 24/7 without loss of sensitivity and requires minimal maintenance. PTI’s VeriCon 126+ offers easy plug & play leak testing solutions for inline container testing and for blowmolding lines with trimmer mount configuration.


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vericon 126+

The VeriCon 135+ is a single station continuous motion leak tester. The technology offers the flexibility to work with different types of conveyor systems and container sizes along with several new-to-market upgrades and enhancements.


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VeriCon 135+

Continuous motion inspection with feedscrew for high speed applications.


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VeriCon 172

Special Applications

package inspection technologies

PTI provides inspection solutions built to fit the most challenging applications. A variety of sensory technology platforms for CCI, package and seal quality inspection are available.

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Setting the Standard

astm testing F2338

PTI technologies were used to develop ASTM F2338 Test Method (Vacuum Decay) and ASTM Test Method F3004 (Airborne Ultrasound).

usp 1207

USP Chapter <1207>: Container Closure Integrity Testing Guidance, Package Integrity Test Method Selection and Validation with overview of Deterministic vs. Probabilistic methods.

ISO

ISO 11607 AND 11608 regulatory guidance documents related to sterile barrier packaging - Requirements for materials and packaging systems.

fda

FDA Recognized Consensus Standards: ASTM F2338 Vacuum Decay Test Method for package integrity testing. ASTM F3004 Airborne Ultrasound Test Method for seal quality & integrity.

PTI Demo center

Automated Container Closure Integrity Testing

Automated container closure integrity testing of parenterals with MicroCurrent HVLD technology

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veripac LPX

Global Leaders in Package Integrity Testing Equipments

PTI is the leading manufacturer of non-destructive package inspection technologies for the pharmaceutical, medical device and food industries. We offer inspection systems for package leak testing, seal integrity and container closure integrity testing (CCIT). Our deterministic test methods eliminate subjectivity and conform to ASTM standards. We specialize in offering the entire solution including test method development and equipment validation.

ptiusa

Our technologies conform to ASTM and other regulatory standards.

Packaging Technologies & Inspection

PTI offers inspection systems for package leak testing, seal integrity and container closure integrity testing (CCIT). Our technologies exclude subjectivity from package testing, and use test methods that conform to ASTM standards. PTI's inspection technologies are deterministic test methods that produce quantitative test result data. We specialize in offering the entire solution including test method development and equipment validation.

Get in Touch

 

Packaging Technologies & Inspection

PTI offers inspection systems for package leak testing, seal integrity and container closure integrity testing (CCIT). Our technologies exclude subjectivity from package testing, and use test methods that conform to ASTM standards. PTI's inspection technologies are deterministic test methods that produce quantitative test result data. We specialize in offering the entire solution including test method development and equipment validation.

ptiusa

Our technologies conform to ASTM and other regulatory standards.

Get in Touch